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Micky D Tortorella Selected Research

aggrecanase

1/2008High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
6/2002Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
2/2002Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

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Micky D Tortorella Research Topics

Disease

10Osteoarthritis
09/2019 - 06/2002
5Arthritis (Polyarthritis)
01/2017 - 02/2002
4Pain (Aches)
01/2017 - 06/2012
3Inflammation (Inflammations)
01/2017 - 10/2015
2Postmenopausal Osteoporosis
05/2022 - 12/2021
2Neoplasms (Cancer)
10/2015 - 01/2009
1Bone Fractures (Bone Fracture)
05/2022
1Osteoporotic Fractures
05/2022
1Malaria
11/2019
1Huntington Disease (Huntington's Disease)
01/2019
1Parkinson Disease (Parkinson's Disease)
01/2019
1Alzheimer Disease (Alzheimer's Disease)
01/2019
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019
1Disease Progression
10/2015
1Hypersensitivity (Allergy)
06/2012
1Knee Osteoarthritis
06/2012
1Hepatolenticular Degeneration (Wilson's Disease)
08/2011
1Inborn Genetic Diseases (Disease, Hereditary)
08/2011
1Atherosclerosis
01/2009
1Rheumatoid Arthritis
09/2006
1type 2 alpha 1 Collagenopathy
11/2003

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
11/2019 - 08/2011
5Aggrecans (Aggrecan)IBA
10/2008 - 06/2002
4Proteins (Proteins, Gene)FDA Link
01/2019 - 06/2002
4EnzymesIBA
08/2013 - 06/2002
3Collagen Type II (Type II Collagen)IBA
10/2008 - 06/2002
3aggrecanaseIBA
01/2008 - 02/2002
2sesaminIBA
05/2022 - 12/2021
2Dinoprostone (PGE2)FDA Link
01/2017 - 01/2016
2Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2017 - 01/2016
2Fibronectins (Fibronectin)IBA
09/2009 - 09/2006
1Estrogens (Estrogen)FDA Link
05/2022
1Antihypertensive Agents (Antihypertensives)IBA
01/2019
1L-Type Calcium Channels (Dihydropyridine Receptor)IBA
01/2019
1Felodipine (Agon)FDA LinkGeneric
01/2019
1BenzopyransIBA
01/2017
1Therapeutic UsesIBA
08/2013
1Peptide Hydrolases (Proteases)FDA Link
08/2013
1Protease Inhibitors (Protease Inhibitor)IBA
08/2013
1Cathepsin KIBA
08/2013
1Amino AcidsFDA Link
06/2012
1Substance PIBA
06/2012
1CurcuminIBA
08/2011
1CopperIBA
08/2011
1Extracellular Matrix ProteinsIBA
01/2009
1Biomarkers (Surrogate Marker)IBA
09/2006
1CollagenIBA
04/2004
1Matrix Metalloproteinases (MMPs)IBA
11/2003
1Messenger RNA (mRNA)IBA
06/2002
1Matrix Metalloproteinase InhibitorsIBA
06/2002
1Transforming Growth Factor beta (TGF-beta)IBA
02/2002

Therapy/Procedure

2Therapeutics
10/2015 - 01/2008
1Transplantation
08/2011
1Autologous Transplantation
08/2011